Migraine Aura

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What triggers migraine aura?

About 15% of migraine patients suffer from migraine with aura. Most patients have visual or sensory symptoms. The assumed mechanism of aura in humans is a phenomenon called spreading cortical depression (1,2). Cortical spreading depression is characterized by a short cortical neuronal excitation followed by long-lasting depression. Both excitation and depression travel across the cortex at a sl...

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Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura.

This study examined the efficacy of lamotrigine in the prevention of migraine aura. Fifty nine patients suffering from migraine with aura received lamotrigine in a controlled three year prospective open study. Treatment response was defined as a reduction of aura frequency each month by at least 50%. Primary endpoint was reached by three quarters of the patients. Lamotrigine significantly reduc...

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Migraine with aura during pregnancy.

CLINICAL HISTORY This is a 38-year-old G2 right-handed woman seen at 28 weeks gestation for headaches. At the age of 13, she started having migraines with aura that were frequent for several years and then became less so for many years. During her prior pregnancy 3 years ago, she had 3 migraines with aura. She had no other similar headaches until 2 months ago. She reports 9 episodes with 4 occu...

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Migraine with persistent visual aura.

CLINICAL HISTORIES Case 1.—This 74-year-old woman was referred by an ophthalmologist with an 8-week history of squiggles in her left field of vision of both eyes inferior more than superior. During the day, if her eyes were closed, she would see kaleidoscope-type letters with a colored background. The visual symptoms were constant except for several hours in the evening when there was total res...

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The Physiology of Migraine Aura

Objectives At the conclusion of this program, participants should be able to: 1. Identify the typical features of migraine aura. 2. Describe the pathophysiologic mechanisms behind migraine aura. 3. Correlate the physiology of cortical spreading depression to the clinical phenomena of migraine aura. 1. Migraine aura is associated with which of the following conditions: a. Cortical spreading depr...

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ژورنال

عنوان ژورنال: Neuron

سال: 2004

ISSN: 0896-6273

DOI: 10.1016/s0896-6273(04)00112-6